Yes, in Missouri a contract to lease is legally binding once both landlord and tenant agree to the essential terms (rent, property, and lease duration) and sign the agreement. Leases longer than one year must be in writing to be enforceable, and after signing, both parties are obligated to follow the lease unless there is a valid termination clause or other legal basis to end it early.
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The information for this answer was found on our Missouri Residential Lease Agreement answers.